Endogenous Antipyretics

[Frontiers in Bioscience 9, 816-826, January 1, 2004] 816 ENDOGENOUS ANTIPYRETICS: NEUROPEPTIDES AND GLUCOCORTICOIDS

Based on observations that fever is suppressed under several physiological circumstances the existence of endogenous antipyretically active molecules has been postulated. A large number of experimental and some clinical studies provided evidence that the neuropeptides arginine vasopressin (AVP), αand γ-melanocyte stimulating hormones (α-MSH, γ-MSH) and adrenocorticotropic hormone (ACTH) as well...

Fever: Its Pathology and Treatment by Antipyretics

Fever: beneficial and detrimental effects of antipyretics.

Although various forms of therapy have been used, since antiquity, to lower the temperature of febrile patients, it is still not known whether the benefits of antipyretic therapy outweigh its risks. Justifications for the use of antipyretic drugs, and the evidence pertaining to these rationales, are examined. Antipyretic therapy in sepsis, and adverse effects of antipyretic medications, are als...

[Use of antipyretics in paediatric emergencies].

20 500 mm (neutrophils: 9200 mm). The comprehensive metabolic panel was normal. The levels of C-reactive protein and procalcitonin were 48.9 mg/L and 4.57 ng/mL, respectively. Since severe splenic sequestration was suspected, an urgent transfusion of red blood cell concentrate was performed, and intravenous (IV) rehydration therapy and empirical treatment with IV ceftriaxone were initiated. The...

Antipyretics: mechanisms of action and clinical use in fever suppression.

Fever is a complex physiologic response triggered by infectious or aseptic stimuli. Elevations in body temperature occur when concentrations of prostaglandin E(2) (PGE(2)) increase within certain areas of the brain. These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus. Although fever benefits the nonspecific immune response to invading microorganis...